Results of a United Kingdom real-world study of polatuzumab vedotin, bendamustine, and rituximab for relapsed/refractory DLBCL

Michael Northend; William Wilson; Wendy Osborne; Christopher P Fox; Andrew J Davies; Dima El-Sharkawi; Elizabeth H Phillips; Hau Wui Sim; Shalal Sadullah; Nimish Shah; Ying Ying Peng; Iman Qureshi; Juanah Addada; Rocio Figueroa Mora; Neil Phillips; Andrea Kuhnl; Elizabeth Davies; David Wrench; Pamela McKay; Indrani Karpha; Anna Cowley; Richard Karim; Sarah Challenor; Vikram Singh; Cathy Burton; Rebecca Auer; Chris Williams; Joel Cunningham; Angus Broom; Anita Arasaretnam; Claire Roddie; Tobias Menne; William Townsend

doi:10.1182/bloodadvances.2021005953

Results of a United Kingdom real-world study of polatuzumab vedotin, bendamustine, and rituximab for relapsed/refractory DLBCL

Blood Adv. 2022 May 10;6(9):2920-2926. doi: 10.1182/bloodadvances.2021005953.

Authors

Michael Northend^{1

2}, William Wilson², Wendy Osborne³, Christopher P Fox⁴, Andrew J Davies⁵, Dima El-Sharkawi⁶, Elizabeth H Phillips^{7

8}, Hau Wui Sim⁹, Shalal Sadullah¹⁰, Nimish Shah¹¹, Ying Ying Peng¹², Iman Qureshi¹³, Juanah Addada¹⁴, Rocio Figueroa Mora⁴, Neil Phillips¹⁵, Andrea Kuhnl¹⁶, Elizabeth Davies¹⁷, David Wrench¹⁸, Pamela McKay¹⁹, Indrani Karpha²⁰, Anna Cowley²¹, Richard Karim²², Sarah Challenor²³, Vikram Singh²⁴, Cathy Burton²⁵, Rebecca Auer²⁶, Chris Williams²⁷, Joel Cunningham¹⁰, Angus Broom²⁸, Anita Arasaretnam²⁹, Claire Roddie¹, Tobias Menne³, William Townsend¹

Affiliations

¹ Department of Haematology, University College Hospital, London, United Kingdom.
² Haematology Trials Team, Cancer Research United Kingdom & UCL Cancer Trials Centre, London, United Kingdom.
³ Department of Haematology, Freeman Hospital, The Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom.
⁴ Department of Haematology, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
⁵ Southampton General Hospital, Southampton Cancer Research United Kingdom/National Institute for Health Research Experimental Cancer Medicines Centre, University of Southampton, Southampton, United Kingdom.
⁶ Department of Haematology, The Royal Marsden Hospital, Sutton, United Kingdom.
⁷ Department of Haematology, The Christie Hospital, Manchester, United Kingdom.
⁸ Division of Cancer Sciences, Faculty of Biology, Medicine and Health, The Christie Hospital, Unit 26, University of Manchester, Manchester, United Kingdom.
⁹ Department of Haematology, Northwick Park Hospital, Middlesex, United Kingdom.
¹⁰ Department of Haematology, James Paget University Hospital, Great Yarmouth, United Kingdom.
¹¹ Department of Haematology, Norfolk & Norwich University Hospital, Norwich, United Kingdom.
¹² Department of Haematology, St George's Hospital, London, United Kingdom.
¹³ Department of Haematology, Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
¹⁴ Department of Haematology, Royal Derby Hospital, University Hospital of Derby & Burton NHS Foundation Trust, Derby, United Kingdom.
¹⁵ Department of Haematology, Royal Stoke University Hospital, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, United Kingdom.
¹⁶ Department of Haematology, King's College Hospital, King's College Hospital NHS Foundation Trust, London, United Kingdom.
¹⁷ Department of Haematology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, United Kingdom.
¹⁸ Department of Haematology, Guy's Hospital, Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.
¹⁹ Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
²⁰ Department of Haematology, The Clatterbridge Cancer Centre, Wirral, United Kingdom.
²¹ Department of Haematology, Eastbourne District Hospital, East Sussex Healthcare NHS Trust, Eastbourne, United Kingdom.
²² Department of Haematology, Dorset County Hospital, Dorchester, United Kingdom.
²³ Department of Haematology, Royal Cornwall Hospital, Treliske, United Kingdom.
²⁴ Department of Haematology, Aintree University Hospital, Liverpool, United Kingdom.
²⁵ Department of Haematology, St James' University Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.
²⁶ Department of Haemato-Oncology, St Bartholomew's Hospital, Bart's Health NHS Trust, London, United Kingdom.
²⁷ Department of Haematology, Hexham General Hospital, Northumbria Healthcare NHS Foundation Trust, Hexham, United Kingdom.
²⁸ Department of Haematology, Western General Hospital, Edinburgh, United Kingdom; and.
²⁹ Department of Haematology, Royal Sussex County Hospital, Brighton & Sussex University Hospitals NHS Trust, Brighton, United Kingdom.

No abstract available

MeSH terms

Antibodies, Monoclonal
Bendamustine Hydrochloride / therapeutic use
Immunoconjugates*
Rituximab / adverse effects

Substances

Antibodies, Monoclonal
Immunoconjugates
Rituximab
Bendamustine Hydrochloride
polatuzumab vedotin