Disruption of Hfe leads to skeletal muscle iron loading and reduction of hemoproteins involved in oxidative metabolism in a mouse model of hereditary hemochromatosis

Biochim Biophys Acta Gen Subj. 2022 Mar;1866(3):130082. doi: 10.1016/j.bbagen.2021.130082. Epub 2022 Jan 4.

¹ Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria 3010, Australia; Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria 3010, Australia.
² Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria 3010, Australia.
³ Molecular Nutrition Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia.
⁴ Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria 3010, Australia.
⁵ Centre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Victoria 3010, Australia. Electronic address: rkoopman@unimelb.edu.au.

No abstract available

Keywords: Hereditary hemochromatosis; Iron overload; Mitochondrial function; Skeletal muscle.

MeSH terms