Nuclear destruction: A suicide mission by AKIRIN2 brings intact proteasomes into the nucleus

Xiang Chen; Kylie J Walters

doi:10.1016/j.molcel.2021.11.020

Nuclear destruction: A suicide mission by AKIRIN2 brings intact proteasomes into the nucleus

Mol Cell. 2022 Jan 6;82(1):13-14. doi: 10.1016/j.molcel.2021.11.020.

Authors

Xiang Chen¹, Kylie J Walters²

Affiliations

¹ Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
² Protein Processing Section, Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA. Electronic address: kylie.walters@nih.gov.

Abstract

de Almeida et al. (2021) developed a temporally controlled CRISPR-Cas9 screen to identify mechanisms controlling MYC levels and discovered that intact proteasomes are imported into the nucleus by AKIRIN2 binding to proteasomes at one end and a nuclear import receptor at the other.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Intramural
Comment

MeSH terms

Active Transport, Cell Nucleus
Cell Nucleus* / metabolism
Humans
Proteasome Endopeptidase Complex / genetics
Proteasome Endopeptidase Complex / metabolism
Suicide*

Substances

Proteasome Endopeptidase Complex

Abstract

Publication types

MeSH terms

Substances

Grants and funding