First results on kinetic modelling and parametric imaging of dynamic 18F-FDG datasets from a long axial FOV PET scanner in oncological patients

Abstract

Purpose: To investigate the kinetics of ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) by positron emission tomography (PET) in multiple organs and test the feasibility of total-body parametric imaging using an image-derived input function (IDIF).

Methods: Twenty-four oncological patients underwent dynamic ¹⁸F-FDG scans lasting 65 min using a long axial FOV (LAFOV) PET/CT system. Time activity curves (TAC) were extracted from semi-automated segmentations of multiple organs, cerebral grey and white matter, and from vascular structures. The tissue and tumor lesion TACs were fitted using an irreversible two-tissue compartment (2TC) and a Patlak model. Parametric images were also generated using direct and indirect Patlak methods and their performances were evaluated.

Results: We report estimates of kinetic parameters and metabolic rate of glucose consumption (MR_FDG) for different organs and tumor lesions. In some organs, there were significant differences between MR_FDG values estimated using 2TC and Patlak models. No statistically significant difference was seen between MR_FDG values estimated using 2TC and Patlak methods in tumor lesions (paired t-test, P = 0.65). Parametric imaging showed that net influx (K_i) images generated using direct and indirect Patlak methods had superior tumor-to-background ratio (TBR) to standard uptake value (SUV) images (3.1- and 3.0-fold mean increases in TBR_mean, respectively). Influx images generated using the direct Patlak method had twofold higher contrast-to-noise ratio in tumor lesions compared to images generated using the indirect Patlak method.

Conclusion: We performed pharmacokinetic modelling of multiple organs using linear and non-linear models using dynamic total-body ¹⁸F-FDG images. Although parametric images did not reveal more tumors than SUV images, the results confirmed that parametric imaging furnishes improved tumor contrast. We thus demonstrate the feasibility of total-body kinetic modelling and parametric imaging in basic research and oncological studies. LAFOV PET can enhance dynamic imaging capabilities by providing high sensitivity parametric images and allowing total-body pharmacokinetic analysis.

Keywords: Dynamic imaging; Kinetic modelling; LAFOV PET; Parametric imaging; Total-body.