Toward noninvasive brain stimulation 2.0 in Alzheimer's disease

Arianna Menardi; Simone Rossi; Giacomo Koch; Harald Hampel; Andrea Vergallo; Michael A Nitsche; Yaakov Stern; Barbara Borroni; Stefano F Cappa; Maria Cotelli; Giulio Ruffini; Georges El-Fakhri; Paolo M Rossini; Brad Dickerson; Andrea Antal; Claudio Babiloni; Jean-Pascal Lefaucheur; Bruno Dubois; Gustavo Deco; Ulf Ziemann; Alvaro Pascual-Leone; Emiliano Santarnecchi

doi:10.1016/j.arr.2021.101555

Toward noninvasive brain stimulation 2.0 in Alzheimer's disease

Ageing Res Rev. 2022 Mar:75:101555. doi: 10.1016/j.arr.2021.101555. Epub 2021 Dec 30.

Authors

Arianna Menardi¹, Simone Rossi², Giacomo Koch³, Harald Hampel⁴, Andrea Vergallo⁴, Michael A Nitsche⁵, Yaakov Stern⁶, Barbara Borroni⁷, Stefano F Cappa⁸, Maria Cotelli⁹, Giulio Ruffini¹⁰, Georges El-Fakhri¹¹, Paolo M Rossini¹², Brad Dickerson¹³, Andrea Antal¹⁴, Claudio Babiloni¹⁵, Jean-Pascal Lefaucheur¹⁶, Bruno Dubois¹⁷, Gustavo Deco¹⁸, Ulf Ziemann¹⁹, Alvaro Pascual-Leone²⁰, Emiliano Santarnecchi²¹

Affiliations

¹ Precision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Padova Neuroscience Center & Department of Neuroscience, University of Padova, PD, Italy.
² Siena Brain Investigation and Neuromodulation Lab, Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Section, University of Siena, Italy.
³ Noninvasive Brain Stimulation Unit, Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy.
⁴ Sorbonne University, GRC No. 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, F-75013 Paris, France.
⁵ Department of Psychology and Neurosiences, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany; Department of Neurology, University Medical Hospital Bergmannsheil, Bochum, Germany.
⁶ Departments of Neurology, Psychiatry and Taub Institute, Columbia University College of Physicians and Surgeons, New York, NY, USA.
⁷ Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
⁸ Institute for Advanced Study-IUSS Pavia, Pavia, Italy; IRCCS Mondino Foundation, Pavia, Italy.
⁹ Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
¹⁰ Neuroelectrics Corporation, 210 Broadway, 02139 Cambridge, MA, USA.
¹¹ Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
¹² Department of Neuroscience & Neurorehabilitation, IRCCS San Raffaele-Pisana, Rome, Italy.
¹³ Frontotemporal Disorders Unit & Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
¹⁴ Department of Clinical Neurophysiology, University Medical Center Göttingen, Georg-August University, Göttingen, Germany.
¹⁵ Department of Physiology and Pharmacology "Erspamer", Sapienza University of Rome, Rome, Italy; San Raffaele of Cassino, Cassino, Italy.
¹⁶ ENT Team, EA4391, Faculty of Medicine, Paris Est Créteil University, Créteil, France; Clinical Neurophysiology Unit, Department of Physiology, Henri Mondor Hospital, Assistance Publique - Hôpitaux de Paris, Créteil, France.
¹⁷ Sorbonne University, GRC No. 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de l'hôpital, Paris, France; Brain & Spine Institute (ICM), INSERM U 1127, CNRS UMR 7225, Boulevard de l'hôpital, Paris, France; Department of Neurology, Institute of Memory and Alzheimer's Disease (IM2A), Pitié-Salpêtrière Hospital, AP-HP, Boulevard de l'hôpital, Paris, France.
¹⁸ Center for Brain and Cognition, Department of Technology and Information, Universitat Pompeu Fabra, Carrer Tànger, 122-140, 08018 Barcelona, Spain; Institució Catalana de la Recerca i Estudis Avançats, Universitat Barcelona, Passeig Lluís Companys 23, 08010 Barcelona, Spain.
¹⁹ Department of Neurology & Stroke, Eberhard-Karls University of Tübingen, Tübingen, Germany; Hertie Institute for Clinical Brain Research, Eberhard-Karls University of Tübingen, Tübingen, Germany.
²⁰ Department of Neurology, Harvard Medical School, Boston, MA, USA; Hinda and Arthur Marcus Institute for Aging Research and Center for Memory Health, Hebrew Senior Life, Boston, MA, USA; Guttmann Brain Health Institute, Institut Guttmann, Universitat Autonoma, Barcelona, Spain.
²¹ Precision Neuroscience & Neuromodulation Program, Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: esantarnecchi@mgh.harvard.edu.

Abstract

Noninvasive brain stimulation techniques (NiBS) have gathered substantial interest in the study of dementia, considered their possible role in help defining diagnostic biomarkers of altered neural activity for early disease detection and monitoring of its pathophysiological course, as well as for their therapeutic potential of boosting residual cognitive functions. Nevertheless, current approaches suffer from some limitations. In this study, we review and discuss experimental NiBS applications that might help improve the efficacy of future NiBS uses in Alzheimer's Disease (AD), including perturbation-based biomarkers for early diagnosis and disease tracking, solutions to enhance synchronization of oscillatory electroencephalographic activity across brain networks, enhancement of sleep-related memory consolidation, image-guided stimulation for connectome control, protocols targeting interneuron pathology and protein clearance, and finally hybrid-brain models for in-silico modeling of AD pathology and personalized target selection. The present work aims to stress the importance of multidisciplinary, translational, model-driven interventions for precision medicine approaches in AD.

Keywords: Alzheimer’s disease; Noninvasive brain stimulation; Precision medicine; Transcranial electrical stimulation; Transcranial magnetic stimulation.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Alzheimer Disease* / therapy
Brain / physiology
Cognition
Humans
Transcranial Direct Current Stimulation* / methods
Transcranial Magnetic Stimulation / methods

Abstract

Publication types

MeSH terms

Grants and funding