Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner

Eur J Immunol. 2022 May;52(5):835-837. doi: 10.1002/eji.202149367. Epub 2022 Jan 17.

Abstract

Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae / genetics
  • Cytokines
  • Interferon Type I*
  • Interleukin-18
  • Receptors, Antigen, T-Cell, gamma-delta / genetics
  • T-Lymphocyte Subsets*

Substances

  • Cytokines
  • Interferon Type I
  • Interleukin-18
  • Receptors, Antigen, T-Cell, gamma-delta