Ultrasound-Guided Optogenetic Gene Delivery for Shock-Free Ventricular Rhythm Restoration

Circ Arrhythm Electrophysiol. 2022 Jan;15(1):e009886. doi: 10.1161/CIRCEP.121.009886. Epub 2021 Dec 23.

Authors

Emile C A Nyns¹, Tianyi Jin², Cindy I Bart¹, Wilhelmina H Bax¹, Guoqi Zhang², René H Poelma², Antoine A F de Vries¹, Daniël A Pijnappels¹

Affiliations

¹ Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center (LUMC), the Netherlands (E.C.A.N., C.I.B., W.H.B., A.A.F.d.V., D.A.P.).
² Department of Microelectronics, Delft University of Technology, the Netherlands (T.J., G.Z., R.H.P.).

PMID: 34937394
DOI: 10.1161/CIRCEP.121.009886

No abstract available

Keywords: defibrillators, implantable; electroshocks; membrane potential; optogenetics; tachycardia.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Channelrhodopsins / genetics
Channelrhodopsins / metabolism
Dependovirus / genetics
Disease Models, Animal
Gene Transfer Techniques*
Genetic Therapy*
Genetic Vectors
Heart Rate*
Hepatitis B Virus, Woodchuck / genetics
Isolated Heart Preparation
Mice, Transgenic
Myosin Heavy Chains / genetics
Optogenetics*
Promoter Regions, Genetic
RNA 3' Polyadenylation Signals
Recovery of Function
Regulatory Elements, Transcriptional
Simian virus 40 / genetics
Tachycardia, Ventricular / genetics
Tachycardia, Ventricular / metabolism
Tachycardia, Ventricular / physiopathology
Tachycardia, Ventricular / therapy*
Ultrasonography, Interventional*

Substances

Channelrhodopsins
Myh6 protein, mouse
Myosin Heavy Chains

Supplementary concepts

Adeno-associated virus-2