Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor

Science. 1987 Jan 16;235(4786):321-4. doi: 10.1126/science.3492043.

Abstract

The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and cell transformation. A synthetic polynucleotide encoding epidermal growth factor conferred a tumorigenic phenotype on cells. These cells were transformed through the action of an autocrine circuit having an extracellular component.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Cell Division
  • Cell Transformation, Neoplastic* / pathology
  • DNA, Recombinant
  • Epidermal Growth Factor / antagonists & inhibitors
  • Epidermal Growth Factor / genetics*
  • Epidermal Growth Factor / immunology
  • Gene Expression Regulation
  • Mice
  • Neoplasms, Experimental / genetics
  • Neoplasms, Experimental / pathology
  • Oncogenes*
  • Rats
  • Transfection

Substances

  • Antibodies, Monoclonal
  • DNA, Recombinant
  • Epidermal Growth Factor