Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors

Juan-Manuel Leyva-Castillo; Raif S Geha

doi:10.1016/j.xjidi.2021.100059

Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct Flavors

JID Innov. 2021 Sep 23;1(3):100059. doi: 10.1016/j.xjidi.2021.100059. eCollection 2021 Sep.

Authors

Juan-Manuel Leyva-Castillo^{1

2}, Raif S Geha^{1

2}

Affiliations

¹ Division of Immunology, Boston Childrens Hospital, Boston, Massachusetts, USA.
² Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

Abstract

In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: skin-resident ILC2s and circulating ILC2s. They show that the circulating subset of skin ILC2s migrates to draining lymph nodes during hapten-induced cutaneous inflammation to potentially enhance the adaptive immune response.