When oncogenes do not cause cancer

Elife. 2021 Dec 9:10:e74912. doi: 10.7554/eLife.74912.

Authors

Jessica Shiu¹, Arthur D Lander²

Affiliations

¹ Department of Developmental and Cell Biology, University of California, Irvine, Irvine, United States.
² Department of Developmental and Cell Biology and the Center for Complex Biological Systems, University of California, Irvine, Irvine, United States.

Abstract

Environmental cues, not oncogene-induced senescence, may stop melanocytes with an activating mutation in the BRAF gene from turning into melanoma.

Keywords: cancer biology; genetics; genomics; human; melanocytes; melanoma; microRNA; mutation; nevi.

© 2021, Shiu and Lander.

Publication types

Editorial
Comment

MeSH terms

Humans
Melanocytes
Melanoma* / genetics
Mutation
Oncogenes / genetics
Proto-Oncogene Proteins B-raf* / genetics

Substances

Proto-Oncogene Proteins B-raf

Grants and funding

KL2 TR001416/TR/NCATS NIH HHS/United States