Abstract
T Cells comprise many subtypes of specified lymphocytes, and their differentiation and function take place in different tissues. This cellular diversity is also observed in the multiple ways T-cell transformation gives rise to a variety of T-cell neoplasms. This review covers the main types of T-cell malignancies and their specific characteristics, emphasizing recent advances at the cellular and molecular levels as well as differences and commonalities among them.
Copyright © 2021 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Chromosome Aberrations
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Humans
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Leukemia, T-Cell / genetics
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Leukemia, T-Cell / metabolism
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Leukemia, T-Cell / pathology*
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Leukemia, T-Cell / therapy
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Lymphoma, T-Cell / genetics
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Lymphoma, T-Cell / metabolism
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Lymphoma, T-Cell / pathology*
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Lymphoma, T-Cell / therapy
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Mutation
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / genetics
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / therapy
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Signal Transduction
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T-Lymphocytes / metabolism
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T-Lymphocytes / pathology*