The Astrocyte Type I Interferon Response Is Essential for Protection against Herpes Simplex Encephalitis

J Virol. 2022 Feb 23;96(4):e0178321. doi: 10.1128/JVI.01783-21. Epub 2021 Dec 8.
No abstract available

Keywords: astrocytes; encephalitis; herpes simplex virus; interferon; microglia.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Astrocytes / immunology*
  • Astrocytes / virology
  • Brain / immunology
  • Brain / virology
  • Disease Models, Animal
  • Encephalitis, Herpes Simplex / immunology*
  • Encephalitis, Herpes Simplex / virology
  • Herpesvirus 1, Human / physiology
  • Interferon Type I / immunology*
  • Kaplan-Meier Estimate
  • Mice
  • Mice, Knockout
  • Microglia / immunology
  • Microglia / virology
  • Receptor, Interferon alpha-beta / deficiency
  • Receptor, Interferon alpha-beta / immunology
  • Signal Transduction
  • Viral Load

Substances

  • Ifnar1 protein, mouse
  • Interferon Type I
  • Receptor, Interferon alpha-beta