Adverse events of inactivated COVID-19 vaccine in HIV-infected adults

Songjie Wu; Yubin Zhang; Fangzhao Ming; Shi Zou; Mengmeng Wu; Wei Guo; Weiming Tang; Ke Liang

doi:10.1186/s12981-021-00416-1

Adverse events of inactivated COVID-19 vaccine in HIV-infected adults

AIDS Res Ther. 2021 Dec 4;18(1):92. doi: 10.1186/s12981-021-00416-1.

Authors

Songjie Wu^#¹, Yubin Zhang^#², Fangzhao Ming^#², Shi Zou³, Mengmeng Wu³, Wei Guo^{4

5}, Weiming Tang^{6

7}, Ke Liang^{8

9

10

11

12}

Affiliations

¹ Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
² Wuchang District Center for Disease Control and Prevention, Wuhan, Hubei, China.
³ Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
⁴ Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.
⁵ Department of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
⁶ Guangdong No. 2 Provincial People's Hospital, University of North Carolina at Chapel Hill Project-China, Guangzhou, 510095, China. Weiming_tang@med.unc.edu.
⁷ The University of North Carolina at Chapel Hill Project-China, Guangzhou, China. Weiming_tang@med.unc.edu.
⁸ Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. keliang@whu.edu.cn.
⁹ Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. keliang@whu.edu.cn.
¹⁰ Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China. keliang@whu.edu.cn.
¹¹ Center of Preventing Mother-To-Child Transmission for Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China. keliang@whu.edu.cn.
¹² Department of Nosocomial Infection Management, Department of Infectious DiseasesCenter of Preventing Mother-To-Child Transmission for Infectious Diseases, Wuhan Research Center for Infectious Diseases and CancerChinese Academy of Medical Sciences, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. keliang@whu.edu.cn.

^# Contributed equally.

Abstract

This study aims to evaluate the safety of inactivated COVID-19 vaccine among adult people living with HIV (PLWH). In total, 259 PLWH who received at least one dose of inactivated COVID-19 vaccine were enrolled, and post-vaccination adverse events (AEs) were evaluated seven days following each vaccination dose. The overall AE frequency was 22.8% after dose one, which was higher than after dose two (10.2%) (P < 0.001). No severe side event or vaccine safety concern was observed. Our finding was essential in reducing vaccine hesitancy among PLWH.

Keywords: Adverse event; COVID-19; Inactivated vaccine; People living with HIV(PLWH).

MeSH terms

Adult
COVID-19 Vaccines
COVID-19*
HIV Infections*
Humans
SARS-CoV-2
Vaccination Hesitancy

Substances

COVID-19 Vaccines

Abstract

MeSH terms

Substances

Grants and funding