Progress in preeclampsia: the contribution of animal models

Katrina Chau; Mikala Welsh; Angela Makris; Annemarie Hennessy

doi:10.1038/s41371-021-00637-x

Progress in preeclampsia: the contribution of animal models

J Hum Hypertens. 2022 Aug;36(8):705-710. doi: 10.1038/s41371-021-00637-x. Epub 2021 Nov 26.

Authors

Katrina Chau^{1

2

3}, Mikala Welsh^{4

5

6}, Angela Makris^{2

3

7}, Annemarie Hennessy^{2

3

8

9}

Affiliations

¹ Department of Renal Medicine, Blacktown Hospital, Blacktown, NSW, Australia.
² School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.
³ Heart Research Institute, University of Sydney, Sydney, NSW, Australia.
⁴ School of Medicine, Western Sydney University, Campbelltown, NSW, Australia. Mikala.Welsh@health.nsw.gov.au.
⁵ Heart Research Institute, University of Sydney, Sydney, NSW, Australia. Mikala.Welsh@health.nsw.gov.au.
⁶ Sydney Local Health District, Camperdown, NSW, Australia. Mikala.Welsh@health.nsw.gov.au.
⁷ South Western Sydney Clinical School, UNSW, Sydney, NSW, Australia.
⁸ Sydney Local Health District, Camperdown, NSW, Australia.
⁹ Campbelltown Hospital, South Western Sydney Local Health District, Campbelltown, NSW, Australia.

Abstract

Recent advances have been made in understanding the nature of placental dysfunction causing preeclampsia, and other hypertensive disorders of pregnancy. The contribution of animal studies in the understanding of the effects of inadequate placentation on blood pressure and other target organs will be explored in this review. This will include technical aspects of animal studies in pregnancy, as well as the translation of data regarding newly discovered pathological pathways, in particular the angiogenic pathway, into targets in clinical practice.

Publication types

Review

MeSH terms

Animals
Blood Pressure
Female
Humans
Models, Animal
Placenta / metabolism
Placentation
Pre-Eclampsia*
Pregnancy