Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review

Jianyi Zhang; Roberto Bolli; Daniel J Garry; Eduardo Marbán; Philippe Menasché; Wolfram-Hubertus Zimmermann; Timothy J Kamp; Joseph C Wu; Victor J Dzau

doi:10.1016/j.jacc.2021.09.019

Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review

J Am Coll Cardiol. 2021 Nov 23;78(21):2092-2105. doi: 10.1016/j.jacc.2021.09.019.

Authors

Jianyi Zhang¹, Roberto Bolli², Daniel J Garry³, Eduardo Marbán⁴, Philippe Menasché⁵, Wolfram-Hubertus Zimmermann⁶, Timothy J Kamp⁷, Joseph C Wu⁸, Victor J Dzau⁹

Affiliations

¹ Department of Biomedical Engineering, School of Medicine, School of Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, USA. Electronic address: jayzhang@uab.edu.
² Institute of Molecular Cardiology, University of Louisville, Louisville, Kentucky, USA.
³ Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA.
⁴ Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles California, USA.
⁵ Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou, University of Paris, PARCC, INSERM, F-75015, Paris, France.
⁶ Institute of Pharmacology and Toxicology, University Medical Center Göttingen, and DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany.
⁷ Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
⁸ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.
⁹ Mandel Center for Hypertension Research, Duke Cardiovascular Center, Duke University School of Medicine, Durham, North Carolina, USA.

Abstract

This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to the authors' own works and opinions on the roadblocks of the field, they discuss novel approaches for cardiac remuscularization via the activation of proliferative mechanisms in resident cardiomyocytes or direct reprogramming of somatic cells into cardiomyocytes. This paper's main mindset is to present current and future strategies in light of their implications for the design of future patient trials with the ultimate objective of facilitating the translation of discoveries in regenerative myocardial therapies to the clinic.

Keywords: heart; heart failure; myocardial infarction; myocyte proliferation; pluripotent stem cell.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Blood Vessel Prosthesis / trends
Cell- and Tissue-Based Therapy / methods
Cell- and Tissue-Based Therapy / trends
Heart Failure / physiopathology
Heart Failure / therapy*
Humans
Myocardial Infarction / physiopathology
Myocardial Infarction / therapy*
Myocytes, Cardiac / physiology
Myocytes, Cardiac / transplantation
Regeneration / physiology*
Regenerative Medicine / methods*
Regenerative Medicine / trends
Review Literature as Topic
Translational Research, Biomedical / methods*
Translational Research, Biomedical / trends
Ventricular Remodeling / physiology*

Abstract

Publication types

MeSH terms

Grants and funding