Companion Tumor Sequencing to Assess the Clinical Significance of Germline Sequencing in Children With Cancer

JAMA Netw Open. 2021 Nov 1;4(11):e2135135. doi: 10.1001/jamanetworkopen.2021.35135.

Authors

Tinaye Mutetwa¹, Catherine Goudie², William D Foulkes^{2

3}, Paz Polak^{1

4}

Affiliations

¹ Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York.
² Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.
³ Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
⁴ Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, New York.

Abstract

This case-control study assesses the clinical significance of germline sequencing in children with cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor / genetics*
Case-Control Studies
Child
Child, Preschool
Female
Genetic Predisposition to Disease*
Germ-Line Mutation*
Humans
Infant
Infant, Newborn
Male
Middle Aged
Neoplastic Syndromes, Hereditary / genetics*
Young Adult

Substances

Biomarkers, Tumor