Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome

P Belohlavkova; F Vrbacky; L Smolej; J Radocha; M Lanska; B Visek; T Kupsa; A Zavrelova; P Zak

doi:10.1016/j.lrr.2021.100274

Prognostic factors affecting the outcome after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome

Leuk Res Rep. 2021 Oct 18:16:100274. doi: 10.1016/j.lrr.2021.100274. eCollection 2021.

Authors

P Belohlavkova¹, F Vrbacky¹, L Smolej¹, J Radocha¹, M Lanska¹, B Visek¹, T Kupsa¹, A Zavrelova¹, P Zak¹

Affiliation

¹ 4th Department of Internal Medicine - Haematology, University Hospital and Charles University, Hradec Kralove, Czech Republic.

Abstract

In the present study, we retrospectively analysed the results of HSCT in 47 consecutive patients with MDS diagnosed at our department between 2002 and 2019, with a focus on possible predictive factors influencing overall survival (OS), the development of relapse, infections, and the occurrence of graft versus host disease (GvHD). In a univariate analysis, the pre-transplantation value of blasts in the marrow < 5% (p = 0.006), the revised International Prognostic Scoring System (IPSS-R) (p = 0.041), and karyotype (p = 0.009) were predictive of OS. Neither the elevation of serum ferritin (> 1000 ug/ml) nor increased C-reactive protein (CRP) (> 5 mg/l) was associated with shorter OS. In contrast, elevated serum lactate dehydrogenase (LDH) (> 213 U/l) was associated with shorter OS (p = 0.04).

Keywords: Allogeneic haematopoietic stem-cell transplantation; Myelodysplastic syndrome; Prognostic factors.

Publication types

Case Reports