Genetic Predictors of Salt Sensitivity of Blood Pressure: The Additive Impact of 2 Hits in the Same Biological Pathway

Hypertension. 2021 Dec;78(6):1809-1817. doi: 10.1161/HYPERTENSIONAHA.121.18033. Epub 2021 Nov 10.

¹ Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.V.H., Y.E.Y., J.S.W., G.K.A., G.H.W.).
² Cell and Molecular Biology Laboratory, Department of Cellular Biology and Pharmacology, Faculty of Medicine and Health Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia (L.E.Y., Y.H.W.).
³ Professor Emeritus, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City (P.N.H.).
⁴ Université de Paris, Inserm U970, Paris Centre de Recherche Cardiovasculaire (X.J.).
⁵ AP-HP, Hôpital Européen Georges Pompidou, Paris (X.J.).
⁶ Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.L.-S.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: aldosterone; allele; blood pressure; glucocorticoids; hypertension.