Objective: To investigate the effects of (+)-catechin and epigallocatechin gallate (EGCG) on alcoholic fatty liver in mice models. Methods: Alcohol and high-fat diet were used to construct the model of alcoholic fatty liver disease, and treated the model with (+)-catechin and EGCG. The effects of (+)-catechin and EGCG were analyzed by detecting the contents of TG, TC, MDA, SOD, ALT and AST in serum and pathological changes of liver. Results: (+)-catechin and EGCG could effectively reduce the contents of TG, TC, MDA, ALT and AST, increase the content of SOD in serum of mice with alcoholic fatty liver disease, improve the degree of liver cell edema and reduce the formation of lipid droplets. Conclusion: (+)-catechin and EGCG could repair liver injury and regulate lipid metabolism of hepatocytes in alcoholic fatty liver disease mice models.
目的： 研究（+）-儿茶素和表没食子儿茶素没食子酸酯（EGCG）对酒精性脂肪性肝病（AFLD）小鼠脂肪肝的影响。 方法： 使用酒精和高脂饮食构建小鼠AFLD模型，建模成功后加以（+）-儿茶素和EGCG干预，并通过检测小鼠血清中甘油三酯（TG）、总胆固醇（TC）、丙二醛（MDA）、超氧化物歧化酶（SOD）、丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）含量及肝脏病理变化，分析（+）-儿茶素和EGCG对小鼠脂肪肝的影响。 结果： （+）-儿茶素和EGCG均可有效降低AFLD模型小鼠血清中的TG、TC、MDA、ALT和AST含量，升高SOD含量，并改善小鼠肝细胞水肿程度、减少脂滴形成。 结论： （+）-儿茶素和EGCG可修复AFLD模型小鼠的肝损伤、调节肝细胞脂代谢。.