Tissue factor activity is increased in neutrophils from JAK2 V617F-mutated essential thrombocythemia and polycythemia vera patients

Am J Hematol. 2022 Feb 1;97(2):E37-E40. doi: 10.1002/ajh.26402. Epub 2021 Nov 14.

Authors

Brandi N Reeves¹, Soo Jin Kim², Jihyun Song², Kathryn J Wilson¹, Michael W Henderson³, Nigel S Key³, Rafal Pawlinski³, Josef T Prchal^{2

4}

Affiliations

¹ Division of Hematology, Blood Research Center and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.
² Division of Hematology, School of Medicine, University of Utah, Salt Lake City, Utah, USA.
³ Division of Hematology and Blood Research Center, University of North Carolina, Chapel Hill, North Carolina, USA.
⁴ Veterans Administration Medical Center, Salt Lake City, Utah, USA.

PMID: 34748652
DOI: 10.1002/ajh.26402

No abstract available

Publication types

Letter

MeSH terms

Blood Coagulation
Humans
Janus Kinase 2 / genetics*
Janus Kinase 2 / metabolism
Neutrophils / metabolism*
Point Mutation
Polycythemia Vera / blood
Polycythemia Vera / genetics*
Polycythemia Vera / metabolism
Thrombocytosis / blood
Thrombocytosis / genetics*
Thrombocytosis / metabolism
Thromboplastin / genetics*
Thromboplastin / metabolism
Up-Regulation

Substances

Thromboplastin
JAK2 protein, human
Janus Kinase 2