Zhikang Capsule Ameliorates Inflammation, Drives Polarization to M2 Macrophages, and Inhibits Apoptosis in Lipopolysaccharide-induced RAW264.7 Cells

Curr Med Sci. 2021 Dec;41(6):1214-1224. doi: 10.1007/s11596-021-2441-z. Epub 2021 Oct 27.

Abstract

Objective: To explore the anti-inflammatory effect of the traditional Chinese medicine Zhikang capsule (ZKC) on lipopolysaccharide (LPS)-induced RAW264.7 cells.

Methods: Safe concentrations of ZKC (0.175, 0.35, and 0.7 mg/mL) were used after the half-maximal inhibitory concentration (IC50) of RAW264.7 cells was calculated through the CCK-8 assay. In addition, the optimal intervention duration of ZKC (0.7 mg/mL) on RAW264.7 cells was determined to be 6 h, since all proinflammatory mediators [tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), inteleukin-6 (IL-6), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and monocyte chemotactic protein-1 (MCP-1)] had a decreasing tendency and relatively down-regulated mRNA expression levels as compared with other durations (4, 8, and 12 h). RAW264.7 cells were pretreated with ZKC at various concentrations (0.175, 0.35 and 0.7 mg/mL) for 6 h and then stimulated with LPS (1 µg/mL) for an additional 12 h.

Results: In terms of inflammation, ZKC could reverse LPS-induced upregulation of TNF-α, IL-1β, IL-6, COX-2, iNOS, and MCP-1 at both the mRNA and protein levels in RAW264.7 cells in a dose-dependent manner. In terms of the NF-κB signaling pathway, ZKC could reduce phosphorylated p65 and promote M2 polarization of RAW264.7 cells under LPS stimulation in a dose-dependent manner. Moreover, ZKC exhibited a protective effect on macrophages from apoptosis.

Conclusion: ZKC exhibited obvious antiinflammatory and anti-apoptotic effects on LPS-induced RAW264.7 cells at the cellular level, and a weakened NF-κB signaling pathway may be a potential significant target.

Keywords: RAW 264.7; Zhikang capsule; apoptosis; inflammation; macrophage; nuclear factor kappa B.

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Drugs, Chinese Herbal / pharmacology*
  • Inflammation / metabolism*
  • Interleukin-1beta / metabolism
  • Lipopolysaccharides / pharmacology*
  • Macrophages / metabolism*
  • Mice
  • RAW 264.7 Cells
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Drugs, Chinese Herbal
  • Interleukin-1beta
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha
  • zhikang capsule