Aerobic oxidation of aldehydes to acids in water with cyclic (alkyl)(amino)carbene copper under mild conditions

Songbo Xu; Xiaomin Zhang; Wenjie Xiong; Ping Li; Wentao Ma; Xingbang Hu; Youting Wu

doi:10.1039/d1cc04812k

Aerobic oxidation of aldehydes to acids in water with cyclic (alkyl)(amino)carbene copper under mild conditions

Chem Commun (Camb). 2022 Feb 10;58(13):2132-2135. doi: 10.1039/d1cc04812k.

Authors

Songbo Xu^{1

2}, Xiaomin Zhang^{1

3}, Wenjie Xiong¹, Ping Li¹, Wentao Ma¹, Xingbang Hu^{1

3}, Youting Wu^{1

3}

Affiliations

¹ School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China. xmzhang@nju.edu.cn.
² Shandong Kanbo Biochemical Technology Co., Ltd, Dongying, 257400, P. R. China.
³ Yuxiu Postdoctoral Institute, Nanjing University, Nanjing 210023, P. R. China.

PMID: 34704994
DOI: 10.1039/d1cc04812k

Abstract

In this work, cyclic (alkyl)(amino)carbene copper ((CAAC)Cu) catalyzed aerobic oxidation of aldehydes in water at room temperature has been reported. Good to excellent yields were obtained using different substrates. A possible reaction mechanism was proposed, in which (CAAC)Cu dioxygen activates the C-H bond of aldehyde with a low barrier of 10.6 kcal mol^-1.