Antifungal-Loaded Calcium Sulfate Beads as a Potential Therapeutic in Combating Candida auris

Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0171321. doi: 10.1128/AAC.01713-21. Epub 2021 Oct 25.

Abstract

Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in health care units, particularly to patients undergoing surgery. The purpose of this study was to investigate the efficacy of antifungal-loaded calcium sulfate (CS) beads in combatting C. auris infection. We demonstrate that the CS-packed beads have the potential to interfere with planktonic and sessile C. auris.

Keywords: Candida auris; antimicrobial; antimicrobial activity; biofilm; calcium sulfate; fungal; wound management.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents* / pharmacology
  • Antifungal Agents* / therapeutic use
  • Biofilms
  • Calcium Sulfate / pharmacology
  • Candida
  • Candida auris*
  • Humans

Substances

  • Antifungal Agents
  • Calcium Sulfate