Evolution of irreversible somatic differentiation

Elife. 2021 Oct 13:10:e66711. doi: 10.7554/eLife.66711.

Abstract

A key innovation emerging in complex animals is irreversible somatic differentiation: daughters of a vegetative cell perform a vegetative function as well, thus, forming a somatic lineage that can no longer be directly involved in reproduction. Primitive species use a different strategy: vegetative and reproductive tasks are separated in time rather than in space. Starting from such a strategy, how is it possible to evolve life forms which use some of their cells exclusively for vegetative functions? Here, we develop an evolutionary model of development of a simple multicellular organism and find that three components are necessary for the evolution of irreversible somatic differentiation: (i) costly cell differentiation, (ii) vegetative cells that significantly improve the organism's performance even if present in small numbers, and (iii) large enough organism size. Our findings demonstrate how an egalitarian development typical for loose cell colonies can evolve into germ-soma differentiation dominating metazoans.

Keywords: evolution of complexity; evolutionary biology; life cycles evolution; major transitions in evolution; none; physics of living systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Evolution*
  • Cell Differentiation*
  • Cell Division*
  • Cell Lineage*
  • Gene Expression Regulation
  • Germ Cells / physiology*
  • Models, Biological*
  • Phenotype

Grants and funding

The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.