The normalized limit of detection in NMR spectroscopy

J Magn Reson. 2021 Nov:332:107077. doi: 10.1016/j.jmr.2021.107077. Epub 2021 Sep 28.

Abstract

We derive the normalized limit of detection for frequency space (nLODf) as a parameter to measure the sensitivity of an NMR spectroscopy setup. nLODf is independent of measurement settings such as bandwidth or number of measurement points, and allows to compare performances of different setups. We demonstrate the usefulness of the new nLODf by comparing the sensitivity of NMR setups from various publications, which all use microcoils. Finally, we want to propose a standard measurement and report format for the sensitivity of new NMR setups.

Keywords: Limit of detection; Microcoil; Nuclear magnetic resonance; Signal-to-noise ratio SNR; Spectroscopy.

Publication types

  • Research Support, Non-U.S. Gov't