Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma

Xiangyu Li; Ming Liu; Junfeng Zhao; Tong Ren; Xin Yan; Lijun Zhang; Xun Wang

doi:10.3389/fphar.2021.750857

Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma

Front Pharmacol. 2021 Sep 23:12:750857. doi: 10.3389/fphar.2021.750857. eCollection 2021.

Authors

Xiangyu Li¹, Ming Liu², Junfeng Zhao¹, Tong Ren¹, Xin Yan³, Lijun Zhang⁴, Xun Wang¹

Affiliations

¹ Department of Neurosurgery, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, China.
² Department of Neurosurgery, Ningde Municipal Hospital Affiliated of Ningde Normal College, Ningde, China.
³ Department of Medical Oncology, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, China.
⁴ Department of Ophthalmology, The Third People's Hospital of Dalian, Non-Directly Affiliated Hospital of Dalian Medical University, Dalian, China.

Abstract

Gliomas are the most common primary tumors of the central nervous system. Due to the existence of the blood-brain barrier and its unique regional immune characteristics, the study of the immune microenvironment of gliomas is particularly important. Glioma stem cells are an important cause of initiating glioma, promoting tumor progression and leading to tumor recurrence. Immunotherapeutic strategies targeting glioma stem cells have become the focus of current research. This paper will focus on the research progress of glioma stem cells in the immune microenvironment of glioma to provide the basis for the immunotherapy of glioma.

Keywords: glioma; glioma stem cells; immune suppression; microenvironment; treatment.

Publication types

Review