Titanium(IV)-Mediated Ring-Opening/Dehydroxylative Cross-Coupling of Diaryl-Substituted Methanols with Cyclopropanol Derivatives

J Org Chem. 2021 Nov 5;86(21):15753-15760. doi: 10.1021/acs.joc.1c01790. Epub 2021 Oct 10.

Abstract

A titanium(IV)-mediated ring-opening/dehydroxylative cross-coupling of diaryl-substituted methanols with a cyclopropanol derivative was developed. The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters in moderate to good yields, which could be applied to the functionalization of complex molecules derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Esters
  • Ethers, Cyclic
  • Methanol*
  • Titanium*

Substances

  • Esters
  • Ethers, Cyclic
  • cyclopropanol
  • Titanium
  • Methanol