Protein levels, air pollution and vitamin D deficiency: links with allergy

Yong Song; E Haydn Walters; Michael J Abramson; Gayan Bowatte; Dinh S Bui; Jennifer Perret; Iain Feather; Luke D Knibbs; Richard Wilson; David S Nichols; Shyamali C Dharmage; Graeme R Zosky

doi:10.1183/23120541.00237-2021

Protein levels, air pollution and vitamin D deficiency: links with allergy

ERJ Open Res. 2021 Oct 4;7(4):00237-2021. doi: 10.1183/23120541.00237-2021. eCollection 2021 Oct.

Authors

Yong Song¹, E Haydn Walters^{2

3}, Michael J Abramson⁴, Gayan Bowatte^{2

5

6}, Dinh S Bui², Jennifer Perret², Iain Feather⁷, Luke D Knibbs⁸, Richard Wilson⁹, David S Nichols⁹, Shyamali C Dharmage², Graeme R Zosky^{1

3}

Affiliations

¹ Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
² School of Population and Global Health, The University of Melbourne, Carlton, Victoria, Australia.
³ Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
⁴ School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
⁵ Faculty of Allied Health Sciences, University of Peradeniya, National Institute of Fundamental Studies, Kandy, Sri Lanka.
⁶ Department of Basic Sciences, Faculty of Allied Health Sciences, University of Peradeniya, Kandy, Sri Lanka.
⁷ Gold Coast Hospital, Southport, Queensland, Australia.
⁸ School of Public Health, The University of Queensland, Herston, Queensland, Australia.
⁹ Central Science Laboratory, University of Tasmania, Hobart, Tasmania, Australia.

Abstract

This study provides novel insights into mechanisms of traffic-related air pollution-induced allergy by down-regulation via complement regulators (CFI, PROS1 and PLG) and its interaction with vitamin D deficiency via the complement inhibitor PLG https://bit.ly/3x0jYOw.