Visible-light-promoted olefinic trifluoromethylation of enamides with CF3SO2Na

Org Biomol Chem. 2021 Sep 14;19(34):7475-7479. doi: 10.1039/d1ob01410b. Epub 2021 Aug 23.

Abstract

A visible-light-promoted olefinic C-H trifluoromethylation of enamides was developed by employing cheap and stable Langlois' reagent as the CF3 source. A series of β-CF3 enamides were obtained in moderate to good yields with high E-isomer selectivity under mild conditions. Preliminary mechanistic studies suggest that molecular oxygen acts as the terminal oxidant for this net oxidative process, and the E isomer selectivity could be well explained by a base-assisted deprotonation of the cation intermediate.

Publication types

  • Research Support, Non-U.S. Gov't