Intracellular drug binding affinities by NMR

Abstract

A commentary on the article by Luchinat et al. [(2021), Acta Cryst. D77, 1247–1258] where they describe an approach to identify the details of a compound binding to a molecular target using in-cell NMR to provide intracellular binding affinities.

Keywords: compound–target interactions; drug development; in-cell NMR; ligand binding affinity.