Epididymal Fat-Derived Sympathoexcitatory Signals Exacerbate Neurogenic Hypertension in Obese Male Mice Exposed to Early Life Stress

Hypertension. 2021 Nov;78(5):1434-1449. doi: 10.1161/HYPERTENSIONAHA.121.17298. Epub 2021 Oct 4.

Abstract

[Figure: see text].

Keywords: adiposity; blood pressure; capsaicin; leptin; serotonin.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue* / innervation
  • Animals
  • Blood Pressure
  • Body Composition
  • Epididymis* / innervation
  • Female
  • Hypertension* / etiology
  • Lipolysis
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity* / complications
  • Stress, Psychological*
  • Sympathetic Nervous System* / physiology