The biodistribution of 67Ga-labelled N-hydroxyamino acid derivatives in tumour-bearing rats

Nucl Med Commun. 1986 Jan;7(1):53-7. doi: 10.1097/00006231-198601000-00007.

Abstract

The biodistribution of 67Ga-labelled complexes of some mono- and di-N-hydroxyamino acid derivatives and of two siderophores (trihydroxamates) were evaluated in Rhabdomyosarcoma-bearing rats. It was found that the mono- and dihydroxamates could not enhance the tumour-localizing properties of 67Ga-citrate, while the 67Ga-labelled trihydroxamates showed very rapid urinary excretion.

MeSH terms

  • Animals
  • Chelating Agents
  • Deferoxamine / analogs & derivatives
  • Ferrichrome / analogs & derivatives
  • Gallium Radioisotopes*
  • Hydroxamic Acids*
  • Radionuclide Imaging
  • Rats
  • Rhabdomyosarcoma / diagnostic imaging*
  • Sarcoma, Experimental / diagnostic imaging
  • Tissue Distribution

Substances

  • Chelating Agents
  • Gallium Radioisotopes
  • Hydroxamic Acids
  • Ferrichrome
  • N-desferriferrichrome
  • N-succinyldesferrioxamine B
  • Deferoxamine