Targeting the mitochondrial unfolded protein response in cancer: opportunities and challenges

Joseph R Inigo; Rahul Kumar; Dhyan Chandra

doi:10.1016/j.trecan.2021.08.008

Targeting the mitochondrial unfolded protein response in cancer: opportunities and challenges

Trends Cancer. 2021 Dec;7(12):1050-1053. doi: 10.1016/j.trecan.2021.08.008. Epub 2021 Sep 24.

Authors

Joseph R Inigo¹, Rahul Kumar¹, Dhyan Chandra²

Affiliations

¹ Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.
² Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA. Electronic address: dhyan.chandra@roswellpark.org.

Abstract

Increasing evidence indicates that a mitochondria-specific stress response referred to as the 'mitochondrial unfolded protein response' (UPR^mt) is activated to maintain mitochondrial integrity and support tumor growth. In this forum article, we discuss the recent advances and current challenges in therapeutically targeting UPR^mt in cancer.

Keywords: cancer; mitochondrial chaperonins; mitochondrial proteases; mitochondrial proteostasis; mitochondrial unfolded protein response.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Mitochondria / metabolism
Neoplasms* / drug therapy
Neoplasms* / genetics
Unfolded Protein Response*

Abstract

Publication types

MeSH terms

Grants and funding