Closing the Rift: Discovery of a novel virus receptor

Nathen E Bopp; Diana Fernández; Patricia V Aguilar

doi:10.1016/j.cell.2021.09.004

Closing the Rift: Discovery of a novel virus receptor

Cell. 2021 Sep 30;184(20):5084-5086. doi: 10.1016/j.cell.2021.09.004. Epub 2021 Sep 23.

Authors

Nathen E Bopp¹, Diana Fernández², Patricia V Aguilar³

Affiliations

¹ Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
² Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
³ Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute for Human Infection and Immunity, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Center for Tropical Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA. Electronic address: pvaguila@utmb.edu.

PMID: 34559984
DOI: 10.1016/j.cell.2021.09.004

Abstract

In this issue of Cell, Ganaie et al. reports the identification of LRP1 as a receptor of the highly pathogenic Rift Valley fever virus. By using genome-wide CRISPR-Cas9 screening and functional studies, Ganaie et al. identified LRP1 and several co-factors as essential elements for virus infection.

Publication types

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MeSH terms

Animals
Receptors, Virus
Rift Valley Fever*
Rift Valley fever virus* / genetics

Substances

Receptors, Virus