ARTS: A Large, International Trial of Thromboprophylaxis in Intra-abdominal, Gynecologic, and Urologic Surgery

Philippe D Violette; Rufus Cartwright; P J Devereaux; Peter L Gross; Kirsi-Maija Kaukonen; Per Morten Sandset; Tuomas P Kilpeläinen; Lauri I Lavikainen; Ville Sallinen; Saana Horstia; Gordon H Guyatt; Kari A O Tikkinen

doi:10.1016/j.euf.2021.08.010

ARTS: A Large, International Trial of Thromboprophylaxis in Intra-abdominal, Gynecologic, and Urologic Surgery

Eur Urol Focus. 2021 Nov;7(6):1222-1225. doi: 10.1016/j.euf.2021.08.010. Epub 2021 Sep 21.

Authors

Affiliations

¹ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada; Department of Surgery, Woodstock General Hospital, Woodstock, Canada.
² Department of Epidemiology and Biostatistics, Imperial College London, London, UK; Department of Obstetrics and Gynaecology, LNWH NHS Trust, London, UK.
³ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada; Department of Medicine, McMaster University, Hamilton, Canada; Population Health Research Institute, Hamilton, Canada.
⁴ Department of Medicine, McMaster University, Hamilton, Canada; Thrombosis and Atherosclerosis Research Institute, Hamilton, Canada.
⁵ Department of Diagnostics and Therapeutics, Anesthesiology and Intensive care, University of Helsinki, Helsinki, Finland; Pharmacovigilance Unit, Finnish Medicines Agency, Helsinki, Finland.
⁶ Department of Haematology, University of Oslo and Oslo University Hospital, Oslo, Norway.
⁷ Department of Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
⁸ Faculty of Medicine, University of Helsinki, Helsinki, Finland.
⁹ Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; Abdominal Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
¹⁰ Faculty of Medicine, University of Helsinki, Helsinki, Finland; Abdominal Center, Helsinki University Hospital, Helsinki, Finland.
¹¹ Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada; Department of Medicine, McMaster University, Hamilton, Canada.
¹² Department of Urology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Surgery, South Karelian Central Hospital, Lappeenranta, Finland. Electronic address: kari.tikkinen@helsinki.fi.

PMID: 34556452
DOI: 10.1016/j.euf.2021.08.010

Abstract

ARTS will be the first trial to compare anticoagulation with a direct oral anticoagulant (apixaban) versus no anticoagulation among patients undergoing intra-abdominal, gynecologic, or urologic surgery at sufficiently similar risk of deep vein thrombosis or pulmonary embolism and major bleeding.

Publication types

Clinical Trial Protocol
Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anticoagulants* / adverse effects
Anticoagulants* / therapeutic use
Female
Hemorrhage / etiology
Humans
Pulmonary Embolism* / etiology
Pulmonary Embolism* / prevention & control
Surgical Procedures, Operative / adverse effects
Venous Thromboembolism* / etiology
Venous Thromboembolism* / prevention & control

Substances

Anticoagulants