Autocrine and paracrine effects of a novel podocyte gene, RARRES1

Anqun Chen; Kyung Lee; John Cijiang He

doi:10.1016/j.kint.2021.07.008

Autocrine and paracrine effects of a novel podocyte gene, RARRES1

Kidney Int. 2021 Oct;100(4):745-747. doi: 10.1016/j.kint.2021.07.008.

Authors

Anqun Chen¹, Kyung Lee², John Cijiang He³

Affiliations

¹ Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, Institute of Nephrology, The Second Xiangya Hospital at Central South University, Changsha, China. Electronic address: anqunchen@csu.edu.cn.
² Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
³ Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Renal Program, James J. Peters Veterans Affairs Medical Center at Bronx, Bronx, New York, USA. Electronic address: cijiang.he@mssm.edu.

Abstract

Retinoic acid receptor responder protein 1 (RARRES1) has been identified as a novel gene for the regulation of podocyte function, and its expression is increased in glomerular disease and associated with disease progression. Increased expression of RARRES1 in podocytes leads to apoptosis through an autocrine effect. Möller-Hackbarth et al. recently found that RARRES1 expression is increased in the endothelial cells in some diseased kidneys to promote podocyte injury, likely through a paracrine effect.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Endothelial Cells
Humans
Kidney Diseases*
Membrane Proteins
Podocytes*

Substances

Membrane Proteins
RARRES1 protein, human

Abstract

Publication types

MeSH terms

Substances

Grants and funding