Role of Artificial Intelligence in Theranostics:: Toward Routine Personalized Radiopharmaceutical Therapies

Julia Brosch-Lenz; Fereshteh Yousefirizi; Katherine Zukotynski; Jean-Mathieu Beauregard; Vincent Gaudet; Babak Saboury; Arman Rahmim; Carlos Uribe

doi:10.1016/j.cpet.2021.06.002

Role of Artificial Intelligence in Theranostics:: Toward Routine Personalized Radiopharmaceutical Therapies

PET Clin. 2021 Oct;16(4):627-641. doi: 10.1016/j.cpet.2021.06.002.

Authors

Julia Brosch-Lenz¹, Fereshteh Yousefirizi¹, Katherine Zukotynski², Jean-Mathieu Beauregard³, Vincent Gaudet⁴, Babak Saboury⁵, Arman Rahmim⁶, Carlos Uribe⁷

Affiliations

¹ Department of Integrative Oncology, BC Cancer Research Institute, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.
² Department of Medicine and Radiology, McMaster University, 1200 Main Street West, Hamilton, Ontario L9G 4X5, Canada.
³ Department of Radiology and Nuclear Medicine, Cancer Research Centre, Université Laval, 2325 Rue de l'Université, Québec City, Quebec G1V 0A6, Canada; Department of Medical Imaging, Research Center (Oncology Axis), CHU de Québec - Université Laval, 2325 Rue de l'Université, Québec City, Quebec G1V 0A6, Canada.
⁴ Department of Electrical and Computer Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.
⁵ Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA; Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA; Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
⁶ Department of Integrative Oncology, BC Cancer Research Institute, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada; Department of Radiology, University of British Columbia, 11th Floor, 2775 Laurel St, Vancouver, British Columbia V5Z 1M9, Canada; Department of Physics, University of British Columbia, 325 - 6224 Agricultural Road, Vancouver, British Columbia V6T 1Z1, Canada.
⁷ Department of Radiology, University of British Columbia, 11th Floor, 2775 Laurel St, Vancouver, British Columbia V5Z 1M9, Canada; Department of Functional Imaging, BC Cancer, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada. Electronic address: curibe@bccrc.ca.

PMID: 34537133
DOI: 10.1016/j.cpet.2021.06.002

Abstract

We highlight emerging uses of artificial intelligence (AI) in the field of theranostics, focusing on its significant potential to enable routine and reliable personalization of radiopharmaceutical therapies (RPTs). Personalized RPTs require patient-specific dosimetry calculations accompanying therapy. Additionally we discuss the potential to exploit biological information from diagnostic and therapeutic molecular images to derive biomarkers for absorbed dose and outcome prediction; toward personalization of therapies. We try to motivate the nuclear medicine community to expand and align efforts into making routine and reliable personalization of RPTs a reality.

Keywords: Artificial intelligence; Dosimetry; Outcome prediction; Quantitative imaging; Radiopharmaceutical therapies; Registration; Segmentation; Theranostics.

Publication types

Review

MeSH terms

Artificial Intelligence
Humans
Nuclear Medicine*
Precision Medicine
Radiometry
Radiopharmaceuticals*

Substances

Radiopharmaceuticals