Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

Shenghua Gao; Tianguang Huang; Letian Song; Shujing Xu; Yusen Cheng; Srinivasulu Cherukupalli; Dongwei Kang; Tong Zhao; Lin Sun; Jian Zhang; Peng Zhan; Xinyong Liu

doi:10.1016/j.apsb.2021.08.027

Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors

Acta Pharm Sin B. 2022 Feb;12(2):581-599. doi: 10.1016/j.apsb.2021.08.027. Epub 2021 Aug 31.

Authors

Shenghua Gao¹, Tianguang Huang¹, Letian Song¹, Shujing Xu¹, Yusen Cheng¹, Srinivasulu Cherukupalli¹, Dongwei Kang^{1

2}, Tong Zhao¹, Lin Sun¹, Jian Zhang¹, Peng Zhan^{1

2}, Xinyong Liu^{1

2}

Affiliations

¹ Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan 250012, China.
² China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province, Ji'nan 250012, China.

Abstract

Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection. Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors with representative examples in different strategies from the medicinal chemistry perspective.

Keywords: Antiviral drugs; COVID-19; Drug design; Medicinal chemistry strategies; SARS-CoV-2.

Publication types

Review