2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model

Vincent Gomez; Mark Cairns; Paul Weinhold; Alexander D Jeffs; Benjamin Bortner; Anthony V Paterno; Laurence Dahners; Reid W Draeger

doi:10.7759/cureus.16758

2-Octyl Cyanoacrylate (Dermabond®) Inhibits Bridging Bone Formation of Articular Fractures in a Rat Model

Cureus. 2021 Jul 30;13(7):e16758. doi: 10.7759/cureus.16758. eCollection 2021 Jul.

Authors

Vincent Gomez¹, Mark Cairns¹, Paul Weinhold¹, Alexander D Jeffs¹, Benjamin Bortner¹, Anthony V Paterno¹, Laurence Dahners¹, Reid W Draeger¹

Affiliation

¹ Department of Orthopaedic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, USA.

Abstract

One technique often used for small intraarticular fracture fixation involves the use of 2-octyl-cyanoacrylate (2-OCTA) (Dermabond®, Ethicon, Inc., Raritan, USA). The purpose of this study was to determine if 2-OCTA impedes bony healing. Osteochondral plugs in 38 retired Sprague-Dawley rats were created in both hind legs. Each rat had one plug dipped in 2-OCTA before fixation and one control plug. H&E staining was used to quantify bone bridging. The 2-OCTA group had a mean bridging bone circumference of 22.80%, significantly less than 67.75% in the control group (p<0.05). Our data suggests that 2-OCTA blocks bridging bone formation, making it a poor choice for fracture fixation.

Keywords: 2-octyl-cyanoacrylate; bone bridging; intraarticular fracture; orif; rat model.