Association of E484K Spike Protein Mutation With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Persons: Maryland, January-May 2021

Kenneth A Feder; Ami Patel; Venkata R Vepachedu; Catherine Dominguez; Eric N Keller; Liore Klein; Curi Kim; Tim Blood; Judie Hyun; Thelonious W Williams; Katherine A Feldman; Heba H Mostafa; C Paul Morris; Jacques Ravel; Monique Duwell; David Blythe; Robert Myers

doi:10.1093/cid/ciab762

Association of E484K Spike Protein Mutation With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Vaccinated Persons: Maryland, January-May 2021

Clin Infect Dis. 2022 Jun 10;74(11):2053-2056. doi: 10.1093/cid/ciab762.

Authors

Kenneth A Feder^{1

2

3}, Ami Patel³, Venkata R Vepachedu³, Catherine Dominguez³, Eric N Keller³, Liore Klein³, Curi Kim³, Tim Blood³, Judie Hyun³, Thelonious W Williams^{3

4}, Katherine A Feldman³, Heba H Mostafa⁵, C Paul Morris^{5

6}, Jacques Ravel⁷, Monique Duwell³, David Blythe³, Robert Myers³

Affiliations

¹ Johns Hopkins Bloomberg School of Public Health, Department of Mental Health, Baltimore, Maryland, USA.
² Epidemic Intelligence Service, Centers for Disease Prevention and Control, Atlanta, Georgia, USA.
³ Maryland Department of Health, Baltimore, Maryland, USA.
⁴ CDC Foundation, Atlanta, Georgia, USA.
⁵ Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁶ National Institute of Allergy and Infectious Diseases, Baltimore, Maryland, USA.
⁷ University of Maryland School of Medicine, Institute for Genomic Sciences, Baltimore, Maryland, USA.

Abstract

Among 9048 people infected with SARS-CoV-2 between January and May 2021 in Maryland, in regression-adjusted analysis, SARS-CoV-2 viruses carrying the spike protein mutation E484K were disproportionately prevalent among persons infected after full vaccination against COVID-19 compared with infected persons who were not fully vaccinated (aOR, 1.96; 95% CI: 1.36-2.83).

Keywords: B.1.351; COVID-19; E484K; L452R; genomic surveillance.

Published by Oxford University Press for the Infectious Diseases Society of America 2021.

Publication types

Research Support, N.I.H., Intramural

MeSH terms

COVID-19 Vaccines / administration & dosage
COVID-19* / epidemiology
COVID-19* / prevention & control
Humans
Maryland / epidemiology
Mutation
SARS-CoV-2* / genetics
Spike Glycoprotein, Coronavirus* / genetics

Substances

COVID-19 Vaccines
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2