The Tunable Photophysical Properties of Enamine Intermediates Involved in Light-Driven Aminocatalysis

Org Lett. 2021 Sep 17;23(18):7033-7037. doi: 10.1021/acs.orglett.1c02387. Epub 2021 Aug 31.

Abstract

In this study, the photosensitive nature of reactive enamine and polyenamine intermediates is investigated to improve our understanding of light-mediated aminocatalytic reactions. Experimental optical absorption data and TD-DFT calculations reveal that these intermediates are excited directly from the HOMO on the enamine moiety to low-lying unoccupied orbitals localized on the catalyst scaffold. This indicates that the photophysical properties of enamine intermediates can be tuned for visible light-mediated reactions by modifications to the aminocatalyst.