Identification of a Functional PDE5A Variant at the Chromosome 4q27 Coronary Artery Disease Locus in an Extended Myocardial Infarction Family

Circulation. 2021 Aug 24;144(8):662-665. doi: 10.1161/CIRCULATIONAHA.120.052975. Epub 2021 Aug 23.

Tan An Dang^#^{1

2}, Thorsten Kessler^#^{1

2}, Jana Wobst^{1

2}, Michael Wierer³, Ingrid Braenne^{4

5}, Tim M Strom^{6

2}, Stephanie Tennstedt^{4

5}, Hendrik B Sager^{1

2}, Thomas Meitinger^{6

7

2}, Jeanette Erdmann^{4

5}, Heribert Schunkert^{1

2}

¹ Department of Cardiology, German Heart Centre Munich (T.A.D., T.K., J.W., H.B.S., H.S.), Technical University of Munich, Germany.
² German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany (T.A.D., T.K., J.W., T.M.S., H.B.S., T.M., H.S.).
³ Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany (M.W.).
⁴ Institute for Cardiogenetics and University Heart Center, University of Lübeck, Germany (I.B., S.T., J.E.).
⁵ German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany (I.B., S.T., J.E.).
⁶ Institute of Human Genetics, Klinikum rechts der Isar (T.M.S., T.M.), Technical University of Munich, Germany.
⁷ Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany (T.M.).

^# Contributed equally.

No abstract available

Keywords: atherosclerosis; genetics; myocardial infarction; nitric oxide; phosphodiesterase 5A.

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