Effects of Transcutaneous Electrical Acupoint Stimulation on Systemic Inflammatory Response Syndrome of Patients after Percutaneous Nephrolithotomy: A Randomized Controlled Trial

Bin Que; Qing Tu; Jinlin Shi; Zhengzuo Wan; Yanan Li; Rong Zhou; Hong Yu; Jianhui Gan; Jianming Yu

doi:10.1155/2021/5909956

Effects of Transcutaneous Electrical Acupoint Stimulation on Systemic Inflammatory Response Syndrome of Patients after Percutaneous Nephrolithotomy: A Randomized Controlled Trial

Evid Based Complement Alternat Med. 2021 Aug 12:2021:5909956. doi: 10.1155/2021/5909956. eCollection 2021.

Authors

Bin Que^#¹, Qing Tu^#², Jinlin Shi³, Zhengzuo Wan¹, Yanan Li¹, Rong Zhou¹, Hong Yu³, Jianhui Gan³, Jianming Yu¹

Affiliations

¹ Department of Anesthesiology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310000, China.
² Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China.
³ Department of Anesthesiology, Tangshan People's Hospital, North China University of Science and Technology, Tangshan, Hebei 063000, China.

^# Contributed equally.

Abstract

Purpose: Transcutaneous electrical acupoint stimulation (TEAS) is widely used. However, no study evaluated TEAS on systemic inflammatory response syndrome (SIRS) of patients after percutaneous nephrolithotomy (PCNL). The study was to evaluate TEAS on SIRS of patients after PCNL.

Methods: 67 patients were enrolled and divided into group TEAS and group sham TEAS. Data were collected from 60 participants finally. In the study, TEAS or sham TEAS on bilateral Shenshu (BL23), Yinlingquan (SP9), Hegu (LI4), and Neiguan (PC6) was performed continuously throughout the procedure. The primary outcome included the incidence of systemic inflammatory response syndrome (SIRS) within 48 h after surgery. The secondary outcomes included the serum levels of inflammatory cytokines, hemodynamics changes, complications, and hospital stay after surgery. The serum levels of tumor necrosis factor- (TNF-) α and interleukin- (IL-) 6, mean arterial pressure (MAP), and heart rate (HR) at 30 min before anesthesia (T ₀), the time after surgery (T ₁), 24 h postoperation (T ₂), and 48 h postoperation (T ₃) were recorded. The consumption of analgesic during surgery was also recorded, as well as the complications and duration of hospital stay after PCNL.

Results: The incidence of SIRS in group TEAS was lower than group sham TEAS (30% vs. 6.67%, p=0.023). Compared with the sham TEAS group, both levels of TNF-α and IL-6 at T ₁, T ₂, and T ₃ were lower in the TEAS group (p < 0.05). The levels of MAP and HR in sham TEAS at T ₁, T ₂, and T ₃ were markedly higher than that in the TEAS group (p < 0.05). The total consumption of propofol and remifentanil during surgery in group TEAS was lower than that in the sham TEAS group. The incidence of hypotension, hypertension, emergence agitation, and postoperative nausea and vomiting (PONV) was also lower in group TEAS after PCNL (p < 0.05).

Conclusions: TEAS could effectively reduce the incidence of SIRS and inflammatory cytokines for patients who underwent PCNL. In addition, TEAS helped to maintain the hemodynamic stability and cut down the consumption of analgesics during PCNL, reducing the complications after PCNL.