Peptide-based system for sensing Pb2+ and molecular logic computing

Anal Biochem. 2021 Oct 1:630:114333. doi: 10.1016/j.ab.2021.114333. Epub 2021 Aug 13.

Abstract

Peptides with recognition, assembly, various activities exhibit strong power and application prospects in sensing, material science, biomedicine. However, peptide-based sensing and expanding application is still at an early stage. Herein, a peptide-based sensing and logic system was developed for highly sensitive and selective detection of Pb2+ and implementation of logic operations. Our Pb2+ assay method was ultra-rapid (less than 1 min), direct, simple with detection limit of 0.75 nM. Flexibility and scalability of peptide-based solution system facilitated the execution of sensing and logic operations from simple to complex. This research will not only inspire discovery and comprehensive applications (such as sensing and assembly) of more functional peptides, but also provide more opportunities for development and design of peptide-based systems and molecular information technologies.

Keywords: Actual sample analysis; Biosensing; Molecular logic; Pb(2+); Peptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques*
  • Fluorescent Dyes / chemistry*
  • Lead / analysis*
  • Molecular Structure
  • Oligopeptides / chemistry*
  • Spectrometry, Fluorescence

Substances

  • Fluorescent Dyes
  • Oligopeptides
  • Lead