Successful use of dupilumab for the treatment of atopic dermatitis on the genitals, a neglected anatomical site

Clin Exp Dermatol. 2022 Jan;47(1):176-178. doi: 10.1111/ced.14894. Epub 2021 Aug 30.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory disease that may involve any cutaneous site; involvement of the genital area may greatly impair patients' quality of life but, as the inspection of genitals is not usually conducted during the routine physical examination of patients with AD, the genital presentation of AD is frequently neglected and under-reported. We decided to evaluate the incidence of genital AD in patients with moderate-severe AD and the relative response to anti-interleukin (IL)-4/IL-13 dupilumab. In our study, a high incidence of genital AD emerged but the use of dupilumab allowed a generalized improvement.

Publication types

  • Letter

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / pathology*
  • Dermatologic Agents / therapeutic use*
  • Female
  • Genitalia, Female / pathology*
  • Genitalia, Male / pathology*
  • Humans
  • Interleukin-4 Receptor alpha Subunit / antagonists & inhibitors*
  • Male
  • Middle Aged
  • Young Adult

Substances

  • Antibodies, Monoclonal, Humanized
  • Dermatologic Agents
  • Interleukin-4 Receptor alpha Subunit
  • dupilumab