Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms

Caiyun Li; Khorshed Alam; Yiming Zhao; Jinfang Hao; Qing Yang; Youming Zhang; Ruijuan Li; Aiying Li

doi:10.3389/fbioe.2021.692466

Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms

Front Bioeng Biotechnol. 2021 Jul 29:9:692466. doi: 10.3389/fbioe.2021.692466. eCollection 2021.

Authors

Caiyun Li¹, Khorshed Alam¹, Yiming Zhao¹, Jinfang Hao¹, Qing Yang², Youming Zhang¹, Ruijuan Li¹, Aiying Li¹

Affiliations

¹ Helmholtz International Lab for Anti-infectives, Shandong University-Helmholtz Institute of Biotechnology, State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China.
² State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.

Abstract

Antimicrobial resistance is one of the most serious public health issues in the worldwide and only a few new antimicrobial drugs have been discovered in recent decades. To overcome the ever-increasing emergence of multidrug-resistant (MDR) pathogens, discovery of new natural products (NPs) against MDR pathogens with new technologies is in great demands. Lanthipeptides which are ribosomally synthesized and post-translationally modified peptides (RiPPs) display high diversity in their chemical structures and mechanisms of action. Genome mining and biosynthetic engineering have also yielded new lanthipeptides, which are a valuable source of drug candidates. In this review we cover the recent advances in the field of microbial derived lanthipeptide discovery and development.

Keywords: biosynthesis; genome mining; lanthipeptide; natural product; pathway engineering.

Publication types

Review