Thirteen undescribed diterpenoid quinones derived from the rhizomes of Salvia miltiorrhiza and their anti-tumor activities

Abstract

Thirteen undescribed diterpenoid quinones were isolated from the dried roots of Salvia miltiorrhiza. Their structures were determined by extensive analysis, including NMR, HRESIMS, and IR. Their absolute configurations were determined by X-ray diffraction, calculated and experimental circular dichroism spectroscopy, and optical rotation. In the evaluation of bioactivities, salviadionether obviously inhibited the proliferation of HCT-116 cells. R-(+)-salmiltiorin E and R-(+)-grandifolia D both showed inhibitory activities on a variety of tumor cells. Salvianone ester A showed strong cytotoxicity to tumor-repopulating cells (TRCs) with an IC₅₀ value of 2.19 μM.

Keywords: Absolute configurations; Anti-tumor activities; Diterpenoid quinones; Lamiaceae; Salvia miltiorrhiza.