Water-Tolerant ortho-Acylation of Phenols

Org Lett. 2021 Aug 20;23(16):6594-6598. doi: 10.1021/acs.orglett.1c02583. Epub 2021 Aug 11.

Abstract

A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C-C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.

Publication types

  • Research Support, Non-U.S. Gov't