Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease

Circ Cardiovasc Interv. 2021 Aug;14(8):e009891. doi: 10.1161/CIRCINTERVENTIONS.120.009891. Epub 2021 Aug 3.

Christopher A Rajkumar^{1

2}, Matthew Shun-Shin^{1

2}, Henry Seligman^{1

2}, Yousif Ahmad^{1

3}, Takayuki Warisawa^{1

4}, Christopher M Cook⁵, James P Howard^{1

2}, Sashiananthan Ganesananthan¹, Laura Amarin¹, Caitlin Khan¹, Ayesha Ahmed⁶, Alexandra Nowbar^{1

2}, Michael Foley^{1

2}, Ravi Assomull^{1

2}, Niall G Keenan⁷, Joban Sehmi⁷, Thomas R Keeble^{5

8}, John R Davies^{5

8}, Kare H Tang⁵, Robert Gerber⁹, Graham Cole^{1

2}, Peter O'Kane¹⁰, Andrew S P Sharp^{11

12}, Ramzi Khamis^{1

2}, Gajen Kanaganayagam², Ricardo Petraco^{1

2}, Neil Ruparelia^{1

2}, Iqbal S Malik², Sukhjinder Nijjer^{1

2}, Sayan Sen^{1

2}, Darrel P Francis^{1

2}, Rasha Al-Lamee^{1

2}

¹ National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.).
² Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.).
³ Columbia University Medical Centre, New York-Presbyterian Hospital (Y.A.).
⁴ St. Marianna University School of Medicine, Yokohama, Japan (T.W.).
⁵ Essex Cardiothoracic Centre, Basildon, United Kingdom (C.M.C., T.R.K., J.R.D., K.H.T.).
⁶ University of Sheffield, United Kingdom (A.A.).
⁷ West Hertfordshire Hospitals NHS Trust, Watford, United Kingdom (N.G.K., J.S.).
⁸ Anglia Ruskin School of Medicine, Chelmsford, Essex, United Kingdom (T.R.K., J.R.D.).
⁹ East Sussex Healthcare NHS Trust, Hastings, United Kingdom (R.G.).
¹⁰ Royal Bournemouth and Christchurch NHS Trust, Bournemouth, United Kingdom (P.O.).
¹¹ University Hospital of Wales, Cardiff, United Kingdom (A.S.P.S.).
¹² University of Exeter, United Kingdom (A.S.P.S.).

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT02062593.

Keywords: angina pectoris; coronary artery disease; hemodynamics; ischemia; percutaneous coronary intervention.