Polydopamine-decorated black phosphorous to enhance stability in polymer scaffold

Guoyong Wang; Guowen Qian; Jia Yao; Weiliang Cai; Shuping Peng; Cijun Shuai

doi:10.1088/1361-6528/ac1977

Polydopamine-decorated black phosphorous to enhance stability in polymer scaffold

Nanotechnology. 2021 Aug 16;32(45). doi: 10.1088/1361-6528/ac1977.

Authors

Guoyong Wang¹, Guowen Qian¹, Jia Yao², Weiliang Cai², Shuping Peng^{3

4}, Cijun Shuai^{1

5

6}

Affiliations

¹ Institute of Bioadditive Manufacturing, Jiangxi University of Science and Technology, Nanchang 330013, People's Republic of China.
² Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
³ NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, School of Basic Medical Science, Central South University, Changsha, 410078 Hunan People's Republic of China.
⁴ School of energy and mechanical engineering, Jiangxi University of Science and Technology, Nanchang 330013, People's Republic of China.
⁵ Shenzhen Institute of Information Technology, Shenzhen 518172, People's Republic of China.
⁶ State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China.

PMID: 34330108
DOI: 10.1088/1361-6528/ac1977

Abstract

Black phosphorous (BP) is recognized as an effective reinforcement for polymer scaffold because of its excellent mechanical property and biocompatibility. Nevertheless, its poor stability in physiological environment limits its application in bone repair. In this work, BP was modified with dopamine by self-polymerization approach (donated as BP@PDA) to improve its stability, and then was introduced into poly-L-lactic acid (PLLA) scaffold fabricated by selective laser sintering technology. Results showed the compressive and tensile strength of PLLA/BP@PDA scaffold were improved by 105% and 50%, respectively. The enhanced strength was ascribed to the increased stability of BP and the improved compatibility of BP@PDA with PLLA matrix after modifying with polydopamine. Simultaneously, the bioactivity of PLLA scaffold was significantly improved. It was attributed to that BP@PDA provided the sustained source ofPO43-ions which could capture Ca²⁺ions from physiological medium to facilitatein situbiomineralization, thereby promoting cell adhesion, proliferation and differentiation. This study demonstrated the great potential of BP@PDA in bone repair.

Keywords: black phosphorus; in-situ biomineralization; mechanical properties; polydopamine.